This undated photo provided by the Oregon Health and Science University in March 2019 shows a baby monkey named Grady, at two weeks old, born from an experimental technology that aims to help young boys undergoing cancer treatment preserve their future fertility. Scientists froze testicular tissue from a monkey that had not yet reached puberty, and later thawed it to produce sperm used for Grady’s conception. (OHSU via AP)

Monkey birth a step to saving fertility of boys with cancer

The technique worked well enough that human testing should begin in the next few years

Scientists are closing in on a way to help young boys undergoing cancer treatment preserve their future fertility — and the proof is the first monkey born from the experimental technology.

More and more people are surviving childhood cancer, but nearly 1 in 3 will be left infertile from the chemotherapy or radiation that helped save their life.

When young adults are diagnosed with cancer, they can freeze sperm, eggs or embryos ahead of treatment. But children diagnosed before puberty can’t do that because they’re not yet producing mature eggs or sperm.

“Fertility issues for kids with cancer were ignored” for years, said University of Pittsburgh reproductive scientist Kyle Orwig. “Many of us dream of growing up and having our own families. We hope our research will help these young patients to do that.”

Orwig’s team reported a key advance Thursday: First, they froze a bit of testicular tissue from a monkey that hadn’t yet reached puberty. Later, they used it to produce sperm that, through a monkey version of IVF, led to the birth of a healthy female monkey named Grady.

The technique worked well enough that human testing should begin in the next few years, Orwig said.

“It’s a huge step forward” that should give hope to families, said Susan Taymans of the National Institute of Child Health and Human Development, which helped fund the research published in the journal Science. “It’s not like science fiction. It’s something that seems pretty attainable.”

University of Pittsburgh Medical Center and a handful of other hospitals already freeze immature testicular tissue from young cancer patients, in hopes of knowing how to use it once they’re grown and ready to have their own children.

Boys are born with stem cells inside little tubes in the testes, cells that start producing sperm after puberty’s testosterone jolt. Orwig’s goal: Keep sperm-producing stem cells safe from cancer treatment by freezing small pieces of testicular tissue, and using them to restore fertility later in life.

How? Enter the monkey research.

Orwig’s team froze tissue from young male monkeys, and then sterilized them. Once the monkeys approached puberty, the researchers thawed those tissue samples and gave them back to the original animal — implanting them just under the skin.

“We’re not hooking it up to the normal plumbing,” Orwig cautioned.

READ MORE: New B.C. pilot to probe how blood tests might improve cancer treatment

Boosted by hormones, the little pieces of tissue grew. Months later, the researchers removed them. Sure enough, inside was sperm they could collect and freeze.

Colleagues at the Oregon National Primate Research Center injected some of that sperm into eggs from female monkeys and implanted the resulting embryos. Last April, Grady was born, and “she plays and behaves just like every other monkey that was grown the normal way,” Orwig said.

If the technique sounds a little bizarre, it’s similar to a female option.

Girls’ eggs are in an immature state before puberty. Researchers have removed and frozen strips of ovarian tissue harbouring egg follicles from young women before cancer treatment, in hopes that when transplanted back later the immature eggs would resume development. It’s considered experimental even for young adults but some births have been reported. Now some hospitals bank ovarian tissue from girls, too.

Surgery involving the boys’ testicular tissue is less invasive, noted Orwig, who also is researching ways to reinsert sperm-producing stem cells where they belong rather than the more roundabout technique.

The new research shows “immature testicular tissue may become an option” to preserve boys’ fertility, Nina Neuhaus and Stefan Schlatt of the Center of Reproductive Medicine and Andrology in Muenster, Germany, wrote in an accompanying editorial.

Meanwhile, “it’s important for parents to know about this,” said Christine Hanlon of Holiday, Florida, who took her son Dylan to Pittsburgh to have his tissue stored when he was newly diagnosed with Ewing’s sarcoma at age 9.

Today Dylan is a healthy teen, and no one knows if he’ll ever need the stored tissue, one of more than 200 samples Orwig’s study has preserved. But Hanlon was thrilled to learn the research is moving along, just in case.

“You lose part of your childhood in cancer treatment,” Hanlon said. “If there was a chance I could help him have normalcy in his future, with the potential of having a family if that’s what he decided to do, I wanted to be able to.”

Lauran Neergaard, The Associated Press

Like us on Facebook and follow us on Twitter.

Just Posted

Ashcroft RCMP looking for witnesses after four-year-old assaulted

Boy was injured in altercation during weekend soccer tournament

Grants will help Chinook and coho get past the damaged Bonaparte fishway

Salmon will be captured and transported around fishway to get to spawning grounds

Graffiti Days 2019 a huge success

Hundreds of cars and spectators — including a History channel TV personality — turned out for the event

Bus company fears for future if another licence issued for Interior routes

Adventure Charters waiting to see if Ebus BC is approved for Prince George-Kamloops run

Sea Cadets wind up another year with Ceremonial Review

Corps is fundraising for a trip to Halifax, Nova Scotia in 2020

VIDEO: Killer whale steals fisherman’s catch off North Coast

Fishing duel results in eager orca snagging salmon in Prince Rupert

Fate of accused in Canadian couple’s 1987 killings in jury’s hands

William Talbott’s lawyer says DNA doesn’t prove murder

Child killed after being hit in driveway on Vancouver Island

The driver of the vehicle remained at the crash scene and is fully cooperating

Eating sandwiches, putting on makeup behind the wheel could land you a fine

RCMP say if you cause an accident while eating you could be penalized

Cat badly hurt in animal trap was likely stuck for days, B.C. owner says

Blu, a three-year-old house cat, suffered severe damage to his hind leg after being stuck in trap for days

40 cats surrendered in apparent hoarding at B.C. home

Officers found the cats living among piles of garbage and feces, suffering from fleas

Vancouver Aquarium drops cetacean ban lawsuit in new lease agreement

Ocean Wise CEO Lasse Gustavsson called the updated lease an exciting new chapter for the aquarium

Thieves steal two $40K chairs featuring gold serpents from B.C. furniture store

Chairs believed to be the only two of its kind in Canada, police said

Rising gas prices force B.C. residents to rethink summer road trips: poll

63 per cent of respondents reported gas prices are impacting their day-to-day finances

Most Read